When the body accumulates too much histamine as a result of either an excessive intake or an inability to properly break it down, it can lead to histamine intolerance. Histamine is a chemical that plays a role in digestion, immune responses and nervous system regulation. In the gut, the enzyme diamine oxidase (DAO) normally aids in the breakdown of histamine. However, histamine accumulates and can result in a variety of symptoms, including bloating and water retention, if DAO levels are low or excessive.
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