Hormones are chemical messengers that control important body functions, such as metabolism, growth, development, and reproduction. Endocrine disorders can cause weight gain in men by disrupting the production or release of these hormones.

The following are some of the most common endocrine disorders that are related to weight gain in men

  1. Hypogonadism

Hypogonadism is a condition in which the testicles are not fully developed. This can lead to low testosterone levels, which can cause weight gain (especially around the abdomen), decreased libido, erectile dysfunction, and fatigue. Hypogonadism can be caused by a number of factors, including genetic disorders, injuries to the testicles, and certain medications.

  1. Cushing’s syndrome

Cushing’s syndrome is a disorder that occurs when the body makes too much of the stress hormone cortisol. Cortisol is a hormone that helps the body to respond to threats/ stress. However, too much cortisol can lead to weight gain, especially around the face and trunk, high blood pressure, and diabetes. Cushing’s syndrome can be caused by a tumour on the adrenal gland or by taking certain medications, such as prednisone.

  1. Acromegaly

Acromegaly is a rare condition in which the pituitary gland produces too much growth hormone. Growth hormone is a hormone that stimulates bone growth and muscle development. However, too much growth hormone can lead to acromegaly, which is characterised by enlarged hands, feet, face, and jaw. Other symptoms of acromegaly include weight gain, skin changes, and joint pain. Acromegaly is usually caused by a tumour on the pituitary gland.

  1. Prolactinoma

A prolactinoma is a type of tumour that grows on the pituitary gland and produces too much of the hormone prolactin. Prolactin is a hormone which  stimulates  production of milk  in  women who are breastfeeding . However, in men, too much prolactin can lead to weight gain, especially around the breasts, galactorrhea (breast milk production in men), and decreased libido. Prolactinomas are usually benign and can be treated with medication.

How Melatonin helps to improve endocrine dysfunction in relation to weight gain?

  • Increased testosterone production 

Melatonin can increase testosterone production by stimulating the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. GnRH then stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which promotes testosterone production in the testicles.

  • Decreased cortisol production

Melatonin can decrease cortisol production by inhibiting the release of corticotropin-releasing hormone (CRH) from the hypothalamus. CRH then stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), which promotes cortisol production in the adrenal glands.

  • Decreased prolactin production

Melatonin can decrease prolactin production by inhibiting the release of prolactin-releasing hormone (PRH) from the hypothalamus. PRH then stimulates the pituitary gland to release prolactin.

  • Improved sperm production and motility

Melatonin can improve sperm production and motility by increasing testosterone levels and decreasing oxidative stress. Testosterone is essential for sperm production and motility, and oxidative stress can damage sperm.

  • Reduced sperm morphology defects 

Melatonin can reduce sperm morphology defects by decreasing oxidative stress. Oxidative stress can damage the DNA of sperm cells, which can lead to morphology defects.

In addition to these direct effects on the endocrine system, melatonin can also help to improve weight gain-related endocrine dysfunction by improving sleep quality. 

Sleep deprivation can disrupt the production of hormones that regulate metabolism and appetite, which can lead to weight gain. Melatonin can help to improve sleep quality by promoting the production of melatonin, a hormone that helps to regulate the sleep-wake cycle.

Overall, melatonin has the potential to improve a number of endocrine dysfunctions that are related to weight gain. Melatonin is a relatively safe and well-tolerated supplement, so it may be a good option for people who are looking for a natural way to improve their endocrine health and lose weight.

Symptoms of endocrine disorders

The symptoms of endocrine disorders can vary depending on the specific disorder. However, some common symptoms include:

  • Unexplained weight gain

  • Fatigue

  • Decreased libido

  • Erectile dysfunction

  • Changes in appetite

  • Skin changes

  • Joint pain

  • High blood pressure

  • Diabetes

Therapy for endocrine diseases associated with male weight gain

Depending on the particular endocrine condition, men’s weight gain-related treatment will differ. Nonetheless, treating the underlying hormonal imbalance is a major component of most therapy. For instance, testosterone replacement treatment may be recommended for males who have hypogonadism. Medication to reduce cortisol production may be used in the treatment of men with Cushing’s syndrome. Additionally, radiation therapy or surgery may be used to eliminate or reduce the pituitary tumour in men with acromegaly.

In addition to medical intervention, lifestyle modifications like diet, exercise, and weight loss can assist manage endocrine diseases associated with male weight gain. Losing weight can lower the likelihood of problems and enhance hormone function. A nutritious diet can aid in lowering inflammation and enhancing general wellness. Additionally, exercise can enhance metabolism and insulin sensitivity.

Modifications in lifestyle can help control weight growth and endocrine disorders

To help manage endocrine disorders and weight loss, lifestyle modifications like diet, exercise, and weight loss can be beneficial in addition to medical treatment.

Weight loss 

Reducing body weight can lower risk of problems and enhance hormone function.


Consuming a wide range of healthy meals is essential for lowering inflammation and enhancing general wellbeing. Pay attention to whole grains, fruits, and veggies. Consume wholesome, unadulterated meals; cut back on carbonated beverages and bad fats.


Exercise can increase metabolism, enhance insulin sensitivity, and aid in weight loss. Make an effort to get at least 30 minutes most days of the week of moderate-intense activity.


Men who have endocrine issues may put on weight. Men who have gained weight without apparent cause should consult a physician to rule out endocrine issues. Improving general health and preventing complications are two benefits of early diagnosis and treatment.

For males with endocrine issues who are attempting to reduce weight, consider the following supplementary advice

Consume a balanced diet that emphasises whole grains, fruits, and vegetables. Minimise carbonated beverages, processed foods and harmful fats.

  • Regular exercise – On most days of the week, try to get at least 30 minutes of moderate-intensity exercise. Exercise increases metabolism, enhances insulin sensitivity, and helps to lose weight.

  • Get enough rest – The average adult needs 7-8 hours each night. Lack of sleep affects hormone levels and might cause weight gain.

  • Control your stress – Stress causes the hormone cortisol to be released, which can result in weight gain. Seek out healthy stress-reduction methods such as yoga, meditation, or physical activity is very important.

    Clinical Dietitian, Simplyweight