What is the difference between Wegovy® and Ozempic®?

What is the difference between Wegovy and Ozempic?

Both contain semaglutide, which is a GLP-1 analogue and are produced by Novo Nordisk pharmaceutical company based in Denmark. Ozempic® and Wegovy® are delivered as weekly injections. GLP or Glucagon Like peptide is a hormone produced by the intestines in response to food intake and helps in

  1. Controlling appetite
  2. Controlling blood sugar
  3. Control intestinal movement

As both medications are GLP-1 analogues, they have similar side effects and safety profile.


Ozempic®

Ozempic® contains Semaglutide and is licensed for blood glucose and weight management in people with type 2 Diabetes mellitus. The starting dose is 0.25mg and is gradually titrated up to 1mg.

Ozempic® is not licensed for weight loss in people who do not have type 2 diabetes.

SUSTAIN research study showed that in patients with type 2 diabetes at high cardiovascular risk, the rate of first occurrence of death from cardiovascular causes, nonfatal heart attack and stroke was significantly lower in those receiving Ozempic® compared to those patients receiving placebo. To read more about further benefits of Ozempic®, please click this link: https://www.nejm.org/doi/full/10.1056/nejmoa1607141

 

Wegovy®

Wegovy® has been approved by FDA for chronic weight management along with life style interventions. The top dose of this weekly injection which contains Semaglutide is 2.4mg.

In the STEP 1 study, participants who were overweight or obese and were given  2.4 mg of Semaglutide once weekly injection in addition to lifestyle intervention had a sustained, clinically relevant reduction in body weight. For more details on the research click this link:https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

We still do not know if Wegovy®, which is higher dose of Semaglutide could be used in people with Type 2 debates who do respond to Ozempic® 1mg.

Please visit this site as we will be updating as an d when research outcomes are released.

 

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Author

Dr C. Rajeswaran FRCP(UK);MSc
Consultant Physician
Obesity, Diabetes & Endocrinology

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