- 0207 299 0388
- Weekday Hours: 10AM - 5PM
*In some cases, if the doctor requires more information, you may be asked to answer follow-up questions or attend a 1-to-1 virtual consultation before a prescription is approved
*In some cases, if the doctor requires more information, you may be asked to answer follow-up questions or attend a 1-to-1 virtual consultation before a prescription is approved
One of the most prevalent adverse effects of perimenopause and menopause, affecting at least 50%
of women, is weight gain. Research from the SWAN and Healthy Women’s studies indicates that women gain roughly 1.5 kg annually throughout perimenopause, adding up to an average weight gain
of 10kg by the time they approach menopause.
Mounjaro can be useful in managing women with menopausal weight gain. After the doctor reviews the patient in a consultation, it will determine if the patient is suitable to use the medication. A medical background check is required so that the patient is 100% safe to take the medication. The patient wouldvstart on the starter dose of 2.5mg if approved for Mounjaro.
Mounjaro can be useful in managing women with menopausal weight gain. After the doctor reviews the patient in a consultation, it will determine if the patient is suitable to use the medication. A medical background check is required so that the patient is 100% safe to take the medication. The patient wouldvstart on the starter dose of 2.5mg if approved for Mounjaro.
Mounjaro works by mimicking the effects of two natural hormones, glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These hormones help to control blood sugar levels by
increasing insulin secretion, slowing gastric emptying, and suppressing glucagon secretion.
Increasing insulin secretion: Mounjaro stimulates the release of insulin from the pancreas, which helps to
lower blood sugar levels.
Slowing gastric emptying: Mounjaro slows down the movement of food from the stomach into the small
intestine, which helps you feel full for longer and eat less.
Suppressing glucagon secretion: Mounjaro reduces the release of glucagon from the pancreas, which helps to
prevent the liver from releasing too much sugar into the bloodstream.
Mounjaro works by mimicking the effects of two natural hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These hormones help to control blood sugar levels by increasing insulin secretion, slowing gastric emptying, and suppressing glucagon secretion.
Increasing insulin secretion:
Mounjaro stimulates the release of insulin from the pancreas, which helps to lower blood sugar levels.
Slowing gastric emptying:
Mounjaro slows down the movement of food from the stomach into the small
intestine, which helps you feel full for longer and eat less.
Suppressing glucagon secretion:
Mounjaro reduces the release of glucagon from the pancreas, which helps to prevent the liver from releasing too much sugar into the bloodstream.
Mounjaro (tirzepatide), primarily approved for treating type 2 diabetes, has shown potential benefits for weight loss, which may appeal to menopausal women experiencing weight gain. Menopause can lead to weight gain due to hormonal changes, decreased metabolism, and increased insulin resistance, all of which contribute to the accumulation of abdominal fat. Although there is no specific research on Mounjaro’s effects exclusively in menopausal women, its effectiveness in promoting weight loss and improving blood sugar control is well documented.
Mounjaro (tirzepatide), primarily approved for treating type 2 diabetes, has shown potential benefits for weight loss, which may appeal to menopausal women experiencing weight gain. Menopause can lead to weight gain due to hormonal changes, decreased metabolism, and increased insulin resistance, all of which contribute to the accumulation of abdominal fat. Although there is no specific research on Mounjaro’s effects exclusively in menopausal women, its effectiveness in promoting weight loss and improving blood sugar control is well documented.
Before recommending Mounjaro for weight management, medical professionals will evaluate a number of aspects, including general health and BMI. If the patient meets the eligibility requirements and the medicine is deemed appropriate for managing their weight, they can be prescribed Mounjaro. There maybe a few factors preventing the prescribing of Mounjaro such as Thyroid cancer or any medical conditions which could be a health risk.
Before recommending Mounjaro for weight management, medical professionals will evaluate a number of aspects, including general health and BMI. If the patient meets the eligibility requirements and the medicine is deemed appropriate for managing their weight, they can be prescribed Mounjaro. There maybe a few factors preventing the prescribing of Mounjaro such as Thyroid cancer or any medical conditions which could be a health risk.
Read our articles on Mounjaro and Wegovy if you would like to learn more about the benefits, the research and case studies.
Mounjaro (tirzepatide) works by mimicking two hormones, GLP-1 and GIP, which are involved in regulating blood sugar and appetite. During menopause, hormonal changes such as declining oestrogen levels can cause metabolic slowdown and increased appetite. Mounjaro addresses these changes by improving insulin sensitivity, helping control hunger, and reducing fat storage.
Currently, there are no known interactions between Mounjaro and hormone replacement therapy (HRT). Many women in menopause take HRT to manage symptoms like hot flushes, mood swings, and vaginal dryness, while also struggling with weight gain and metabolic issues. Mounjaro works to improve insulin sensitivity and aid in weight loss, so it can be used alongside HRT to provide a more holistic approach to managing both the hormonal and metabolic changes that occur during menopause.
Weight regain is common if lifestyle changes are not maintained after stopping Mounjaro. Continuing a balanced diet and regular exercise is key to sustaining weight loss in the long term, even after medication ends.
Weight loss varies from individual to individual. However, when combined with balanced, nutritious eating, regular physical activity, and a holistic approach, the weight loss potential with Mounjaro can be significant. With guidance and support from a healthcare expert team, including doctors and dietitians, some women may lose between 15 and 22% of their body weight over 12 to 18 months of treatment, according to studies.
Yes, Mounjaro improves insulin sensitivity, a key factor in managing menopausal weight gain. Insulin resistance, which is common during menopause, makes it harder to burn fat and maintain a healthy weight. Mounjaro enhances insulin function and regulates glucose, reducing fat storage. This not only supports weight management but also lowers the risk of developing metabolic conditions, such as type 2 diabetes, which are more common during and after menopause.
The most common side effects of Mounjaro are nausea, vomiting, fatigue, headaches and diarrhoea, especially in the early weeks of treatment. These are usually temporary and subside as the body adjusts, though they don’t occur in everyone. In rare cases, Mounjaro may cause more serious side effects, such as pancreatitis, thyroid tumours, or gastroparesis, but these are very rare and not common.
Mounjaro does not increase oestrogen levels. It works by mimicking the hormones GLP-1 and GIP and may help manage weight gain and insulin resistance associated with menopause but does not affect oestrogen or other sex hormones. For addressing low oestrogen during menopause, hormone replacement therapy (HRT) would be more appropriate.
No, Mounjaro cannot reverse menopause. Menopause is a natural biological process that marks the end of a woman’s menstrual cycles and is primarily driven by a decrease in oestrogen and other hormones. However, Mounjaro helps to alleviate some symptoms related to menopause, such as weight gain, by addressing metabolic issues.
Yes, Mounjaro can help manage emotional eating by reducing overall hunger and cravings. Since it improves insulin sensitivity and helps regulate blood sugar, it can prevent blood sugar spikes and crashes that often trigger emotional eating.
Yes, Mounjaro is generally safe for long-term use in menopausal women when monitored by a healthcare provider. It is effective for weight loss and metabolic health, but side effects like nausea can occur, especially early on. Regular check-ups are important to ensure safety and effectiveness over time.
Mounjaro may help improve energy levels in menopausal women by regulating appetite, stabilising blood sugar, and supporting weight loss. Many women experience fatigue and sluggishness during menopause, but Mounjaro can help reduce hunger, prevent energy crashes, and enhance overall vitality. This makes it easier for women to stay active and feel more energised throughout the day.
Book an Appointment Today
Sign-up using your e-mail to regularly receive useful
& interesting weight loss information!
By clicking signup you agree to our Privacy Policy and Terms of Use
All consultations and prescriptions are carried out by GMC registered medical practitioners.
All dispensing and shipping of medicines are completed by a UK licensed, GPhC registered Pharmacy no: 9011284.
CloudRx is our partner pharmacy and prescribing service.
*Disclaimer: Results may vary from person to person depending on individual engagement and commitment to the programme.
The content of this website is provided for general informational purposes only and is not intended as, nor should it be considered a substitute for, professional medical advice. Do not use the information on this website for diagnosing or treating any medical or health related condition. If you have or suspect you have a medical problem, promptly contact your healthcare provider.
© 2025 The London Obesity Clinic
